Scientist, DMPK
frontage laboratories
Exton, PA
Full-time
Science
Posted on September 13, 2018
For a contract research organization (Frontage Laboratories, Inc. – Exton, PA): conduct in vitro and in vivo metabolism studies using radiolabeled and non-radiolabeled compounds; analyze samples using HPLC coupled to radioactivity detectors and MS detectors (Orbitrap, ion trap, triple stage quadruple instruments) and propose structures of metabolites and metabolic pathways; develop robust sample analysis method and perform metabolites identification, synthesis and isolation in various matrices; design and synthesize custom chemistry library and prodrug and perform compound optimization.
Requirements:
- Ph.D. or foreign equivalent degree in Medicinal Chemistry, Analytical Chemistry, Pharmacokinetics or a related field.
- 1 year experience in job offered or 1 year research experience. Will accept research experience gained while pursuing graduate degree. This required experience must include 1 year experience in structural optimization in early drug discovery, custom synthesis, prodrug design and synthesis and small molecules drug metabolism studies.
- Proficiency in LC-MS/MS, NMR, HPLC, in vivo ADME animal IV, IP dosing, blood and tissue collection and PK protein binding assays.